Ellen O'Dea
Chemistry and Biochemistry Graduate Student (5th Year)
Email
Ellen
Office: 858-822-4673
B.S. Chemistry and Biochemistry,
California Polytechnic State University
San Luis Obispo, 2004
Research Interests
I am a fourth year biochemistry graduate student and joined the group in December of 2004. In my tenure in the lab, I have studied the mechanism of NF-kappaB nuclear translocation in response to UV stimulation. This mechanism is novel in that it does not require the activation of IKK, a requisite for the more studied TNF and LPS inflammatory responses. More currently, I am exploring the requirement of basal IKK activity for IkappaB degradation and translational control and subsequent NF-kappaB activation.
Publications
| Citation | Link |
|---|---|
| Encoding NF-kB temporal control in response to TNF: distinct roles for the negative regulators IkBa and A20. Werner SL*, Kearns JD*, Zadorozhnaya V, Lynch C, O'Dea EL, Boldin MP, Ma A, Baltimore D, Hoffmann A. Genes and Development, 22, pp. 2093-2101 (2008) |
PubMed,PDF |
| UV as an amplifier rather than inducer of NF-kappaB activity. O'Dea EL, Kearns JD, Hoffmann A. Mol Cell, 30(5), pp. 632-41 (2008) |
PubMed,PDF |
| NF-kB Dictates the degradation pathways of IkBa. Mathes E, O'Dea EL, Hoffmann A, Ghosh G. EMBO, 27(9), pp. 1357-67 (2008) |
PubMed,PDF |
| A homeostatic model of IkB metabolism to control constitutive activity. O'Dea EL, Barken D, Peralta RQ, Tran KT, Werner SL, Kearns JD, Levchenko A, Hoffmann A. Molecular Systems Biology, 3:111, pp. 1-7 (2007) |
PubMed,PDF |
| A fourth IkB protein within the NF-kB Signaling Module. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea EL, Werener SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. Cell, 128, pp. 369-381 (2007) |
PubMed,PDF |