Alexander Hoffmann
Professor
Email Alex
Office: 858-822-4670
Ph.D. Rockefeller University, 1994
B.A. Cambridge University 1988
Research Interests
Alex's interests began to focus on biology when undergraduate research on topoisomerases instilled in him a sense of discovery that seemed to be missing while earning his undergraduate degree in Physics at Cambridge. During his graduate research with Dr. Bob Roeder at Rockefeller University, he identified TBP and some components of the TFIID complex. During his postdoctoral training with Dr. David Baltimore at MIT and Caltech, he first focused on HIV and then aimed to understand the dynamic control of the NFkB signaling network and its ability to produce distinct gene expression programs. Reactivating rudimentary undergraduate math skills, and with the help of smart students and postdocs, Alex has pursued at UCSD a Systems Biology approach in order to understand how molecular networks produce immune responses to pathogens and noxious agents.
Alex is PI of the Signaling Systems Laboratory at UCSD and the San Diego Center for Systems Biology; he is Professor of Chemistry and Biochemistry and Director of the Graduate Program in Bioinformatics and Systems Biology.
