Publications
Recent Publications
| Citation | Link |
|---|---|
| UV as an amplifier rather than inducer of NF-kappaB activity. O'Dea EL, Kearns JD, Hoffmann A. Mol Cell, 30(5), pp. 632-41 (2008) |
PubMed,PDF |
| NF-kB Dictates the degradation pathways of IkBa. Mathes E, O'Dea EL, Hoffmann A, Ghosh G. EMBO, 27(9), pp. 1357-67 (2008) |
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| Stabilization of RelB requires multidomain interactions with p100/p52. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. J Biol Chem., 283(18), pp. 12324-32 (2008) |
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| Epigenetic control: slow and global, nimble and local. Cheng CS, Johnson TL, Hoffmann A. Genes and Development, 22(9), pp.1110-1114. (2008) |
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| Generation and Activation of multiple dimeric transcription factors within the NF-kB signaling system. Basak S, Shih VF, Hoffmann A. Molecular and Cellular Biology, 28(10), pp. 3139-3150. (2008) |
PubMed,PDF |
Reviews and Perspectives
| Inflammatory Tales of Liver Cancer. Hoffmann A, Xia Y, Verma IM. Cancer Cell, 11, pp. 99-101 (2007) |
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| Transcriptional Regulation via the NF-kB Signaling Module. Hoffmann A, Natoli G, Ghosh G. Oncogene 25, pp. 6706-6716 (2006) |
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| Circuitry of NF-kB Signaling. Hoffmann A, Baltimore D. Immunological Reviews, 210, pp.171-186 (2006) |
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Mathematical Modeling of Signaling
| A homeostatic model of IkB metabolism to control constitutive activity. O'Dea EL, Barken D, Peralta RQ, Tran KT, Werner SL, Kearns JD, Levchenko A, Hoffmann A. Molecular Systems Biology, 3:111, pp. 1-7 (2007) |
PubMed,PDF |
| A fourth IkB protein within the NF-kB Signaling Module. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea EL, Werener SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. Cell, 128, pp. 369-381 (2007) |
PubMed,PDF |
| IkBe provides negative feedback to control NF-kB oscillations, signaling dynamics, and inflammatory gene expression. Kearns JD, Basak S, Werener SL, Huang CS, Hoffmann A. J. Cell Biol., 173, pp.659-664 (2006) |
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| Transient IKK activity mediates NF-kB temporal dynamics in response to a wide range of TNFa doses. Cheong R, Bergmann A, Werner SL, Regal J, Hoffmann A, Levchenko A. J. Biol. Chem., 281, pp. 2945-50 (2006) |
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| Stimulus-specificity of gene expression programs determined by temporal control of IKK activity. Werener SL, Barken D, Hoffmann A. Science, 309, pp.1857-61 (2005) |
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| Comment on "Oscillations in NF-kB Signaling Control of Dynamics of Gene Expression" Barken D, Wang CJ, Kearns JD, Cheong R, Hoffmann A, Levchenko A. Science 308, pp.52a (2005) |
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| The NF-kB/IkB signaling module: temporal control and selective gene activation. Hoffmann A, Levchenko A, Scott M, Baltimore D. Science, 298, pp. 1241-1245 (2002) |
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NF-kB in Physiology and Pathology
| Coordination between NF-kB family members p50 and p52 is essential for mediating LTbR signals in the development and
organization of secondary lymphoid tissues. Lo JC, Basak S, James ES, Quiambao R, Kinsella MC, Alegre M-L, Weih F, Franzoso G, Hoffmann A, Fu Y.-X. Blood, 107, pp.1048-55 (2006) |
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| Immortalized Fibroblasts from NF-kB Rel knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation with v-Ras. Gapuzan M-ER, Schmah O, Pollock AD, Hoffmann A, Gilmore T. Oncogene, 24, pp.6574-83 (2005) |
PubMed,PDF |
| Innate immunity conferred by B-cells is regulated by capsase-8. Beisner DR, Chen IL, Kolla RV, Hoffmann A, Hedrick SM. J. Immunol. 175, pp.3469-73 (2005) |
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| Initiation and termination of NF-kB signaling by the intracellular protozoan Toxoplasma gondii. Shapira S, Harb OS, Margarit J, Matrajt M, Han J, Hoffmann A, Freedman B., May MJ, Roos DS, Hunter CA J. Cell Sci. 118, pp.3501-3508 (2005) |
PubMed,PDF |
| Subcytocidal attack by staphylococcal alpha-toxin activates NF-kB and induces interleukin-8 production. Dragneva Y, Anuradha CD, Valeva A, Hoffmann A, Bhakdi S, Husmann M. Infect. Immun. 69, pp.2630-2635 (2001) |
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| Suppression of steady-state, but not stimulus-induced NF-kB activity inhibits alphavirus-induced apoptosis. Lin K-I, DiDonato JA, Hoffmann A, Hardwick JM, Ratan RR. J. Cell Biol. 141, pp. 1479-1487 (1998) |
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Regulation of NF-kB
| CK2 is a C-terminal IkB kinase responsible for NF-kB activation during the UV response. Kato T, Delhase M, Hoffmann A, Karin M. Mol. Cell, 12, pp.829-839 (2003) |
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| Double stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70 and stabilization of ARE containing HSP70 mRNA during stress. Zhao M, Tang D, Lechpammer S, Hoffmann A, Asea A, Stevenson MA, Calderwood SK. J. Biol. Chem., 277, pp. 44539-47 (2002) |
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| Nuclear localization of IkBa is mediated by the second ankyrin repeat: The IkBa ankyrin repeats define a novel class of cis-acting nuclear import sequences. Sachdev S, Hoffmann A, Hannink M. Mol. Cell. Biol. 18, pp. 2524-2534 (1998) |
PubMed,PDF |
Regulation by NF-kB
| Signaling Pathways and Genes that inhibit pathogen-induced macrophage apoptosis: CREB and NF-kB as Key Regulators. Park JM, Greten FL, Wong A, Westrick RJ, Arthur JSC, Otsu K, Hoffmann A, Montminy M, Karin M. Immunity, 23, pp.319-29 (2005) |
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| A c-Rel subdomain responsible for enhanced DNA binding and selective gene activation. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. Genes Dev, 19, pp.2138-51 (2005) |
PubMed,PDF |
| Molecular determinants of crosstalk between nuclear receptors and Toll-like Receptors mediating
counter-regulation of inflammatory responses. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK Cell, 122, pp.707-21 (2005) |
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| Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. J. Biol. Chem., 280, pp.29256-62 (2005) |
PubMed,PDF |
| One nucleotide in a kB site can determine cofactor specificity for NF-kB dimers. Leung TH, Hoffmann A, Baltimore D. Cell, 118, pp.453-464 (2004) |
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| Unique CD40-mediated biological program in B-cell activation requires both type 1 and type 2 NF-kB pathways. Zarnegar B, He J, Hoffmann A, Baltimore D, Cheng G. PNAS, 101, pp.8108-8113 (2004) |
PubMed,PDF |
| Genetic analysis of NF-kB/Rel transcription factors reveals molecular specificities. Hoffmann A, Leung TH, Baltimore D. EMBO J., 22, pp.5530-9 (2003) |
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| Cooperation of multiple signaling pathways in CD-40-regulated gene expression in B lymphocytes. Dadgostar H, Zarnegar B, Hoffmann A, Qin X-F, Truong U, Rao G, Baltimore D, Cheng G. PNAS 99, pp1497-1502 (2002) |
PubMed,PDF |
| Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST. Nat. Immunol. 2, pp. 51-57 (2001) |
PubMed,PDF |
| Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kB but not C/EBP or c-Jun. Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, Pope RM. J. Immunol. 165, pp. 7199-7206 (2000) |
PubMed,PDF |
| Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST. PNAS 97, pp. 12705-12710 (2000) |
PubMed,PDF |