Previous Publications by Alexander Hoffmann

Recombinant Protein Expression and Structure Determination (1988-1995)

Nikolov, D.B., Chen, H., Halay, E.D., Hoffmann, A., Roeder, R.G., Burley, S.K. 1996. Crystal structure of a human TATA box-binding protein/TATA element complex. Proc. Natl. Acad. Sci. USA 93, pp. 4862-4867.
Xie, X.-L., Kokubo, T., Cohen, S., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K. 1996 Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature 380, No.6572, pp. 316-322.
Nikolov, D.B., Hu, S.-H., Lin, J., Gasch, A., Hoffmann, A., Horikoshi, M., Chua, N.-H., Roeder, R.G., Burley, S.K. 1992. Crystal structure of TFIID TATA-box binding protein. Nature 360, pp. 40-46.
Hoffmann, A. and Roeder, R.G. 1991. Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies. Nucleic Acids Research 19, No.22, pp. 6337-6338.

RNA Pol II General Transcription Factors: Molecular Characterization (1988-1995)

Hoffmann, A., Oelgeschlager, T., Roeder, R.G. 1997 Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions ? Proc. Natl. Acad. Sci. USA 94, pp. 8928-8935.
Segil, N., Guermah, M., Hoffmann, A., Roeder, R.G., Heintz, N. 1996 Mitotic regulation of TFIID: Inhibition of activator-dependent transcription and changes in sub-cellular localization. Genes & Development 10, pp. 2389-2400.
Hoffmann, A. and Roeder, R.G. 1996 Cloning and characterization of human TAF20/15: multiple interactions suggest a central role in TFIID complex formation. J. Biol. Chem. 271, pp. 18194-18202.
Hoffmann, A., Chiang, C.-M., Oelgeschlager, T., Burley, S.K., Nakatani, Y., Roeder, R.G. 1996 A histone octamer-like structure within TFIID. Nature 380, No.6572, pp. 356-359.
Hoffmann, A. and Roeder, R.G. 1994 A molecular characterization of the general transcription factor IID. Ph.D. Thesis, The Rockefeller University.
Chiang, C.-M., Ge, H., Wang, Z., Hoffmann, A., Roeder, R.G. 1993. Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III. EMBO J. 12, pp. 2749-2762.
Takada, R., Nakatani, Y., Hoffmann, A., Kokubo, T., Hasegawa, S., Roeder, R.G., Horikoshi, M. 1992. Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID). Proc. Natl. Acad. Sci. USA 89, pp. 11809-11813.
Ohkuma, Y., Sumimoto, H., Hoffmann, A., Shimazaki, S., Horikoshi, M., Roeder, R.G. 1991. Structural motifs and potential homologies in the large subunit of human general transcription factor TFIIE. Nature 354, pp. 398-401.
Tamura, T., Sumita, K., Fujino, I., Aoyama, A., Horikoshi, M., Hoffmann, A., Roeder, R.G., Mikoshiba, K. 1991. Striking homology of the variable N-terminal as well as the conserved core domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Research 19, No.14, pp. 3861-3865.
Gasch, A., Hoffmann, A., Horikoshi, M., Roeder, R.G., Chua, N.H. 1990. Arabidopsis thaliana contains two genes for TFIID. Nature 346, No.6282, pp.390-394.
Hoffmann, A., Sinn, E., Yamamoto, T., Wang, J., Roy, A., Horikoshi, M., Roeder, R.G. 1990. Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature 346, No.6282, pp.387-390.
Hoffmann, A., Horikoshi, M., Wang, C. K., Schroeder, S., Weil, P.A., Roeder, R.G. 1990. Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID. Genes & Development 4, pp. 1141-1148

Other

Kinoshita, K., Kaneda, Y., Sato, M., Saeki, Y., Wataya-Kaneda, M., Hoffmann, A., Kaneda, Y. 1998 LBP-p40 binds DNA tightly through associations with histones H2A. H2B, and H4. Biophys. Biochem. Res. Commun. 253, pp. 277-282.
Hoffmann, A., Heck, M.M.S., Bordwell, B.J., Rothfield, N.F., Earnshaw, W.C. 1989. Human autoantibody to topoisomerase II. Exp. Cell Res. 180, pp. 409-418.